Biomarker Facts

What are biomarkers and how are they used in colorectal cancer? Learn about biomarkers, their role in personalized medicine, and their impact on your treatment.
fact about colorectal cancer biomarkers
Biomarker treatment impact tables diagram

Biomarker Overview and Treatment Impact Table

Learn about different colorectal cancer biomarkers and how they affect your treatment options.

Biomarkers

Colorectal Cancer Biomarkers

Microsatellite Stability (MSS)

Learn about microsatellite stability (MSS) and how it affects your colorectal cancer treatment options.

Microsatellite Instability (MSI)

Learn about microsatellite instability (MSI, MSI-High, MSI-H) and how it affects your colorectal cancer treatment options.

KRAS

Learn about the KRAS biomarker and how it affects your colorectal cancer targeted therapy options.

NRAS

Learn about the NRAS biomarker and how it affects your colorectal cancer targeted therapy options.

BRAF

Learn about the BRAF biomarker and how it affects your colorectal cancer targeted therapy options.

Carcinoembryonic Antigen (CEA)

Learn about the carcinoembryonic antigen (CEA) biomarker and how it is used in the diagnosis, monitoring, and treatment of your colorectal cancer.

HER2

Learn about HER2 amplification / over expression and what it means for your colorectal cancer treatment.

Tumor Mutational Burden (TMB)

Learn about tumor mutational burden (TMB) and how it affects your colorectal cancer treatment options.

Tumor Location / Tumor Sidedness

Learn about how right-sided colon cancer and left-sided colorectal cancer are different and how that affects your prognosis and treatment.

NTRK Fusion

Learn about NTRK fusion and how it can be a treatment target in the management of your colorectal cancer.

PIK3CA

Learn about the PIK3CA biomarker and how it affects your colorectal cancer targeted therapy options.

Circulating Tumor DNA (ctDNA)

Learn how ctDNA and liquid biopsy are used in your colorectal cancer biomarker testing, treatment response monitoring, and diagnosis of cancer recurrence.
Syndromes

Colorectal Cancer Syndromes

Lynch Syndrome

Learn about Lynch Syndrome, also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC), a cancer syndrome caused by deficient DNA mismatch repair (dMMR).

Familial Adenomatous Polyposis (FAP)

Learn about familial adenomatous polyposis (FAP), an inherited genetic colorectal cancer syndrome, and how it affects you and your family.
Biomarkers

Toxicity Biomarkers

DPYD

Learn about the DPYD biomarker and fluorouracil (5-FU) treatment toxicity in colorectal cancer.

UGT1A1

Learn about the UGT1A1 biomarker and irinotecan treatment toxicity in colorectal cancer.